The mature paternity threatens the child with defective genes

The mature paternity threatens the child with defective genes

Men who become fathers at late age, transfer the to children more defective genes. The increase in age of the father for one year is accompanied by emergence on the average 2 harmful mutations in a genome of their descendants, RIA Announcements reports.

The group of scientists of Institute of genetics of deCODE in Reykjavik compared number of mutations in genomes of fathers, mothers and newborn kids in 78 Icelandic families.

It appeared that on the average the genome of each kid contained 60 mutations which are absent at his parents. But at all this twenty years’ fathers transferred to descendants of only 25 new mutations, and the kids conceived by 40-year-old men, contained in own genome already about 65 anomalies. At all this mothers actually did not influence genetic "health" of own kids – on the average, they transferred to children on 15 mutations regardless of their age.

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The exclusive role of the father in genetic health of posterity is explained by distinctions in an origin of ova and spermatozoa. Ladies’ sexual sections are formed till the birth of their owner, and new ova do not arise in the childhood and adult life. And here spermatozoa are continuously updated in the course of a cycle сперматогенеза which duration makes only two months. As the man grows old, quality of its sperm is made heavier, as explains growth of mutations at posterity of mature young men.

On view of a number of scientists, the congestion of anomalies in a genome in an extent of several generations can lead to fierce consequences for posterity health. But, as it was confirmed earlier, the kids who were born at fathers aged, become long-livers more often.

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